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Even though the opiate receptor relies on G protein coupling for signal transduction, this receptor was observed to benefit from arrestin activation for internalization with the receptor. Otherwise, the receptor promoted no other signaling cascades (fifty nine) Modifications of conolidine have resulted in variable improvement in binding efficacy. T… Read More

Early research suggests that conolidine may not maximize tolerance in individuals. Thereby supplying a stable and efficient therapy for pain without the require for escalating doses.Innovations within the knowledge of the cellular and molecular mechanisms of pain as well as qualities of pain have resulted in the discovery of novel therapeutic avenu… Read More

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